Hays Travel has opened a new branch in Widnes, Cheshire.
The shop will occupy a 1,526 sq ft two-storey unit in the town centre on a 10 year lease.
A branch in Moreton, Wirral opened in June and further openings are planned in Hove, Basingstoke, Southsea, Southport and Ormskirk.
Last month the agency chain also acquired CAS Travel in Norfolk, taking over its two shops in in Alysham and Sheringham.
The openings will bring the number of shops in the Hays Travel portfolio to 156: 72 in the south, 59 in the north and 25 in the northwest.
Hays Travel employs more than 1,000 people and last year its sales exceeded £800 million.