Biman Bangladesh Airlines is resuming flights from Manchester to Dhaka and Sylhet from Boxing Day.
The airline plans to fly twice a week until March 28 using Boeing 787 Dreamliner aircraft.
Return economy fares start at £680 and business class from £1,796.
The first flight will depart from Manchester on Sunday, and then will operate on Fridays and Mondays from December 30.
Manchester airport managing director Karen Smart said: “There has been significant demand for a direct service to Bangladesh for many years, so when the route returned in 2019 it was greatly received.
“It is therefore really positive news to see the route return as the aviation sector begins its road to recovery.
“Within our catchment area there are many long-standing Bangladeshi communities for whom this will make a massive difference.
“There is also a great number of northern companies who trade with Bangladesh, and many more with a desire to do so, meaning this route is a real boost for them and will unlock and enable many business opportunities.”