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A US tourist was killed and several people wounded in a spate of attacks near Tel Aviv and in Jerusalem in Israel.
The American, named as Taylor Force, was one of 10 people stabbed by an attacker in Jaffa, south of Tel Aviv.
US vice-president Joe Biden was at an event close by at the time.
Earlier, two Israeli police officers were shot and wounded in occupied East Jerusalem. An ultra-Orthodox Jew was stabbed in Petah Tikva, near Tel Aviv.
Israeli police said the attackers in all three incidents had been killed, the BBC reported.
The attacker in Jaffa reportedly stabbed a number of people in the port area, before moving through the city attacking others. Five of the wounded are in a serious condition.
The American stabbed to death has been identified as a student at Vanderbilt University in Nashville, Tennessee.
Taylor Force was on a trip to Israel to learn more about global entrepreneurship and start-ups, university chancellor Nicholas Zeppos told his fellow students.
Others on the trip were safe and unharmed, Mr Zeppos said, calling the incident a "horrific act of violence".
Biden, who had been attending an event with former Israeli president Shimon Peres in the nearby Peres Centre for Peace at the time, "condemned in the strongest possible terms the brutal attack" and "expressed his sorrow at the tragic loss of American life", the White House said.
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