New routes to Los Angeles and Boston are to be launched by Thomas Cook Airlines from Manchester next summer.
They will be the only routes to the two US cities from outside London, building on the airline's new transatlantic services to New York JFK and Miami.
New York will see frequency rise to six flights a week from May 2016, Orlando will gain a daily service in the peak summer season and Las Vegas will see frequency increase to up to six flights a week.
Thomas Cook Airlines will be the biggest long-haul carrier at Manchester airport, with a fleet of six aircraft, with an additional Airbus A330 being added in 2016.
Feeder flights are being made available to the North Atlantic network from a range of UK regional airports with Flybe, and from across Europe with SAS and Lufthansa.
Thomas Cook chief airlines and hotels officer, Christoph Debus, said: “We are incredibly proud to have the largest non-stop route network from Manchester airport, with 15 long haul destinations including six to the USA - more long-haul routes than any other carrier from Manchester.
“Based on our relationship with Manchester Airports Group, we will continue to grow passenger numbers by over 20% including further developing our long haul network by 50% in summer 2016.
“With Manchester as a hub for our airlines across Europe as a gateway to the USA, today’s announcement of new routes to Los Angeles and Boston is great news for our customers with even more choice from outside London.”
MAG managing director, Ken O’Toole, added: "MAG has a very strong relationship with Thomas Cook Airlines, and the expansion at Manchester continues to confirm the airport as the UKs global gateway from the North.
“The announcement of services to Los Angeles and Boston, which makes Manchester the only airport outside of London to offer them, complements Thomas Cook's recent launches of New York and Miami.
“With over 22 million people living within our two hour catchment, two full length runways and all-time record passenger numbers, Manchester airport is, and will continue to have, the available capacity and demand to meet the needs of our catchment that extends as far north as Scotland and South to the Midlands.”
The airline confirmed last year that it is introducing long haul services from Stansted this summer with flights to Cancun, Las Vegas and Orlando from July, and has committed to retaining its current flight programme from East Midlands airport.
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