Flybe is to pull off the London City-Dublin route in the face of heightened competition.
The regional airline will withdraw flights in May, just seven months after seeking to establish a network of services from the Docklands airport.
An Inverness service has already been dropped and frequency to Exeter has been reduced.
Other destinations served include Aberdeen, Belfast and Edinburgh.
But the carrier has faced the introduction of five daily flights between London City and Dublin by British Airways.
A spokesman for the Exeter-based airline said: “Flybe has a disciplined approach to the routes it operates, which means we continually review our network to ensure that we offer the right choice of destinations for our customers.
“Following a review of the London City-Dublin route's operation, passenger numbers and profitability, Flybe has regretfully taken the decision to suspend the service with the last flight operating on May 31.
“Despite our competitive pricing structure, overall passenger numbers are below our projections and there are no signs of this situation changing, which has led to us taking this decision.
“Passengers who have booked to fly on this route are being contacted and offered an alternative flight or a full refund.
“We sincerely apologise for any inconvenience this may cause our customers.”
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