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An American guest was injured in an explosion at the Traders Hotel in Burma's main city of Rangoon.
It is the latest in a series of small explosions in Burma, which is also known as Myanmar.
One blast occurred at a guesthouse in central Burma on Friday and two more in Rangoon on Sunday, reports say.
The latest explosion blew out a window in a guest's room, shooting shards of thick glass more than 98ft into the street in the city's central business district, according to the Associated Press.
An American woman was taken to hospital with minor injuries. The US embassy said it was providing her with consular assistance.
The device reportedly went off in the guest's bathroom.
"It was a time bomb. It was attached to a clock," a police official was quoted as saying by AFP news agency.
"The hotel management is working with the local authorities who are investigating this incident," said Phillip Couvaras, general manager of the hotel, which is popular with visiting officials and foreign tourists, the BBC reported.
No-one has claimed responsibility for the blasts.
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