Thomas Cook Group is to cut 2,500 jobs across its back office and retail network.
The group also plans to close 195 stores as part of the restucture of the UK business.
A 90 day consultation begins today over the future of 2,500 jobs, both back office and retail. The group currently employs 15,500 people in the UK.
The back office roles will include staff at the head offices in Peterborough and Preston. The consultation also includes the proposed closure of the Accrington office.
Stores will close which do "not meet the performance targets of the business" and are in areas where Thomas Cook has more than one retail outlet.
Peter Fankhauser, chief executive Continental Europe & UK, said: "It is never easy to make decisions that impact directly on our people, but we also owe it to our customers to shape the business effectively and ensure that, when they book their holiday with us, our administrative costs are as low as possible.
"As we improve and develop our online capabilities, maintaining a strong presence on the High Street is an important part of our omni-channel strategy. Even after these changes we will still have one of the largest retail networks in UK travel.
He added: "It is essential that we operate with the right number of people as we move forward into the next era for our company, allowing us to meet the future needs of our customers more effectively.
"These proposals will mean a stronger Thomas Cook that continues to be a major employer in the UK dedicated to providing excellent holiday experiences to our 23 million customers. We are in consultation with our unions and employee representative bodies to minimise the impact of these changes and I am speaking personally to all employees today to provide information and support through this period of consultation."
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