New Royal Caribbean International ship Odyssey of the Seas will make its debut in Italy to kick off its inaugural European season next summer.

The 4,284-passenger vessel will operate from Civitavecchia, the port for Rome, on a series of Mediterranean itineraries from April 2021.

The line also confirmed that Anthem of the Seas will sail from Southampton after this summer’s schedule was cancelled due to the Covid-19 pandemic.

The vessel will feature new ports of call in Denmark, France and Norway as part of a series of cruises, ranging from seven-night Norwegian fjords to 14-night Mediterranean cities itineraries.

The ex-UK departures are scheduled to run between May and October.

Vision of the Seas¸ previously planned to sail from Barcelona, will instead operate from San Juan, Puerto Rico on Caribbean itineraries.

Adventure of the Seas will now sail from Barcelona with a mix of 4 and 5-night short Mediterranean itineraries instead of original plans to operate from Copenhagen and Stockholm.

Jewel of the Seas, originally planned to homeport in Amsterdam and Barcelona, will now sail from Stockholm and Copenhagen on 7-night cruises to Helsinki, Tallinn and Visby in Sweden.

In other changes, Royal Caribbean ships will sail from additional US cruise ports next summer including Tampa and San Juan in Puerto Rico.

Independence of the Seas, originally sailing from Fort Lauderdale on 3- and 4-night cruises, will move to Miami to offer a combination of 6- and 8-night cruises to the southern and western Caribbean, visiting islands including Aruba and Curacao.

Brilliance of the Seas will stay in Tampa for the summer offering a series of short cruises to the Caribbean.

The line line’s biggest season in Alaska will see four ships deployed, including newcomer Quantum of the Seas.

Mariner and Navigator of the Seas will run 3-night weekend and 4-night weekday itineraries to The Bahamas and private island Perfect Day at CocoCay.

Oasis of the Seas is set to cruise from the New York area for the first time.

Spectrum of the Seas will offer 4- and 5-night sailings from Shanghai including calls to Japan.

The line said: “Guests with confirmed bookings between April and November 2021 and whose cruises are affected by these changes are being notified directly.”