NCL Freestyle Cruising is to stop ex-Southampton sailings in 2010.
Norwegian Jade will sail out of Barcelona while Norwegian Gem will sail from the port of Venice.
The company says it is part of a strategy to simplify NCL's European offer while providing greater choice as the demand for fly-cruise grows.
Norwegian Jewel will continue to operate out of the UK operating its Baltics itinerary round-trip from Dover.
NCL UK general manager Stephen Park said: "The accessibility of Venice by air and the convenience of seven-night sailings means the itineraries will appeal to a new younger demographic, whilst experienced cruisers have the option of 14-night back-to-back sailing."
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